MORPHOLOGICAL BASIS OF VASCULAR DYSFUNCTION ASSOCIATED WITH VASOPRESSOR USE IN INTENSIVE CARE
Abstract
Vasopressors (norepinephrine, vasopressin, phenylephrine, epinephrine) remain the cornerstone of maintaining perfusion of vital organs in septic, cardiogenic, and hypovolemic shock. However, prolonged or high-dose vasopressor therapy is frequently associated with the development of refractory vasoplegia, ischemia–reperfusion organ injury, and multiple organ dysfunction.
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