ASTRAGALUS (ASTRAGALUS MEMBRANACEUS BUNGE): BOTANICAL, GEOGRAPHICAL, AND HISTORICAL ASPECTS TO PHARMACEUTICAL COMPONENTS AND BENEFICIAL ROLE.
Abstract
Medicinal plants always are part of folk medicine and are nowadays receiving worldwide attention for prophylaxis, management, and treatment of several diseases, as an alternative to chemical drugs. The current work provided a comprehensive overview and analysis of the Astragalus and health relationship in literature. The analysis of their therapeutic potential is thus instrumental to understand their bioactivity. Among these, the flowering medicinal plant Astragalus membranaceus has raised interest due to several beneficial health effects. This perspective review discussed the botanical, geographical, historical, and the therapeutic properties of A. membranaceus, with a special focus on its health improving effects and medicinal applications both in vitro and in vivo.
References
1. Adesso S, Russo R, Quaroni A, Marzocco S (2018) Astragalus membranaceus extract attenuates inflammation and oxidative stress in intestinal epithelial cells via NF-κB activation and Nrf2 response. Intern J Mol Sci 19(3):800
2. Ahmed MS, Hou SH, Battaglia MC, Picken MM, Leehey DJ (2007) Treatment of idiopathic membranous nephropathy with the herb Astragalus membranaceus. Am J Kidney Dis 50(6):1028–1032
3. Ali M, Khan T, Fatima K, Ali QUA, Ovais M, Khalil AT, Ullah I, Raza A, Shinwari ZK, Idrees M (2018) Selected hepatoprotective herbal medicines: evidence from ethnomedicinal applications, animal models, and possible mechanism of actions. Phytother Res 32(2):199–215.
4. Atanasov AG, Zotchev SB, Dirsch VM, International Natural Product Sciences Taskforce, Supuran CT (2021) Natural products in drug discovery: advances and opportunities. Nat Rev Drug Discov 20(3):200–216.
5. Attorre F, Pignatti S, Spada F et al (2018) Introduction: vegetation science and the habitats directive: approaches and methodologies of a never-ending story. Rend Fis Acc Lincei 29:233–235.
6. Awad A, Khalil SR, Hendam BM, Abd El-Aziz RM, Metwally MMM, Imam TS (2020) Protective potency of Astragalus polysaccha rides against tilmicosin-induced cardiac injury via targeting oxidative stress and cell apoptosis-encoding pathways in rat. Environ Sci Pollut Res Int 27(17):20861–20875.
7. Berezutsky M, Durnova N, Vlasova I (2019) Experimental and clinical studies of mechanisms of the anti-aging effects of chemical compounds in Astragalus membranaceus (review). Adv Geron 32(5):702–710.
8. Bratkov VM, Shkondrov AM, Zdraveva PK, Krasteva IN (2016) Flavo noids from the genus Astragalus: phytochemistry and biological activity. Pharmacogn Rev 10(19):11–32.
9. Brush J, Mendenhall E, Guggenheim A, Chan T, Connelly E, Soumy anath A, Buresh R, Barrett R, Zwickey H (2006) The effect of Echinacea purpurea, Astragalus membranaceus and Glycyr rhiza glabra on CD69 expression and immune cell activation in humans. Phytother Res 20(8):687–695.
10. Cao Y, Shen T, Huang X, Lin Y, Chen B, Pang J, Li G, Wang Q, Zohrabian S, Duan C (2017) Astragalus polysaccharide restores autophagic flux and improves cardiomyocyte function in doxoru bicin-induced cardiotoxicity. Oncotarget 8(3):4837–4848.
11. Chan WS, Durairajan SSK, Lu JH, Wang Y, Xie LX, Kum WF, Koo I, Yung KKL, Li M (2009) Neuroprotective effects of Astragaloside IV in 6-hydroxydopamine-treated primary nigral cell culture. Neurochem Intern 55(6):414–422.
12. Chang X, Lu K, Wang L, Lv M, Fu W (2018) Astraglaus polysaccha ride protects diabetic cardiomyopathy by activating NRG1/ErbB pathway. Biosci Trends 12(2):149–156.
13. Chao YH, Wu KH, Lin CW, Yang SF, Chao WR, Peng CT, Wu HP (2017) PG2, a botanically derived drug extracted from Astragalus membranaceus, promotes proliferation and immunosuppression of umbilical cord-derived mesenchymal stem cells. J Ethnopharmacol 207:184–191.
14. Chen J, Zhao X, Li X, Wu Y (2015) Calycosin induces apoptosis by the regulation of ERβ/miR-17 signaling pathway in human colorectal cancer cells. Food and Funct 6(9):3091–3097.
15. Chen SL, Yu H, Luo HM, Wu Q, Li CF, Steinmetz A (2016) Conservation and sustainable use of medicinal plants: problems, progress, and prospects. Chin Med 11(1):37–46.
16. Chen W, Ju J, Yang Y, Wang H, Chen W, Zhao X, Ye H, Zhang Y (2018) Astragalus polysaccharides protect cardiac stem and progenitor cells by the inhibition of oxidative stress-mediated apoptosis in diabetic hearts. Drug Des Devel Ther 12:943–954.
17. Chen Y, Bi L, Luo H, Jiang Y, Chen F, Wang Y, Wei G, Chen W (2019) Water extract of ginseng and Astragalus regulates macrophage polarization and synergistically enhances DDP’s anticancer effect. J Ethnopharmacol 232:11–20.
18. Cheng S, Zhang X, Feng Q, Chen J, Shen L, Yu P, Yang L, Chen D, Zhang H, Sun W (2019) Astragaloside IV exerts angiogenesis and cardioprotection after myocardial infarction via regulating PTEN/PI3K/Akt signaling pathway. Life Sci 227:82–93.
19. Cho J, Cho C, Shin J, Son J, Kang W, Son C (2009) Myelophil, an extract mix of Astragali Radix and Salviae Radix, ameliorates.
