KADMIY INTOKSIKATSIYASIDA KALAMUSH JIGARI MITOXONDRIYALARI DISFUNKSIYASINI IZOKINOLIN ALKALOIDLARI VA ULARNING KON’YUGATLARI BILAN KORREKSIYALASH MEXANIZMLARI
Abstract
Maqolada kadmiy intoksikatsiyasi sharoitida kalamush jigari mitoxondriyalarida yuzaga keladigan funksional va metabolik buzilishlarning shakllanish mexanizmlari hamda ularni izokinolin alkaloidlari va ularning mitoxondriyaga yo‘naltirilgan kon’yugatlari yordamida korreksiyalashning fiziologik asoslari tahlil qilingan. Kadmiy ta’sirida mitoxondrial nafas olishning buzilishi, ichki membrana potensialining pasayishi, adenozintrifosfat sintezining kamayishi, reaktiv kislorod turlarining ortiqcha hosil bo‘lishi, lipid peroksidlanishining kuchayishi va kalsiy homeostazining izdan chiqishi jigar hujayralarining energetik ta’minoti hamda yashovchanligiga salbiy ta’sir ko‘rsatishi mumkin. Adabiyotlar tahlili berberin va palmatin kabi izokinolin alkaloidlarining antioksidant, yallig‘lanishga qarshi va mitoxondrial metabolizmni modulyatsiya qiluvchi xususiyatlarga ega ekanligini ko‘rsatadi. Ayniqsa, plastoxinon bilan kon’yugatsiyalangan SkQBerb va SkQPalm birikmalari mitoxondriyaga selektiv yo‘naltirilishi va oksidlovchi shikastlanishni kamaytirish imkoniyati bilan ajralib turadi. Shu bilan birga, ushbu birikmalarning kadmiy intoksikatsiyasida qo‘llanish mexanizmlarini baholashda ularni kadmiyni xelatlovchi vositalar sifatida emas, balki asosan mitoxondrial redoks muvozanatini himoya qiluvchi yo‘naltirilgan antioksidantlar sifatida ko‘rib chiqish lozim.
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